Changes in noradrenaline and dopamine levels under oxygen debt conditions in the brain of rats during experimental acute pancreatitis

This study’s aim was to assess the level of catecholamines, i.e., noradrenaline and dopamine, under oxygen debt conditions in brain experimental animals which acute pancreatitis experimentally induced. Catecholamines play role neurotransmitters neuromediators. They are responsible for regulation motor emotional processes, take part hormonal activities, sleep, wakefulness, concentration, attention, learning processes. The experiment also determined tension as an indicator respiratory failure activity amylase lipase development inflammatory process. on conducted were Wistar rats (140 animals) divided into 3 research groups: control (C) (n = 30), healthy (H) operated (O) 80). determination amylase, lipase, pressure, NA, DO levels performed at hours 2, 6, 12, 24, 48 experiment. group C had injection needle inserted investigate only effects mechanical damage organs. On other hand, O a 5% solution sodium taurocholate introduced common bile-pancreatic duct. shows that most significant changes NA observed first day concentrations above catecholamines statistically significantly correlated with blood. peak dopamine between 6th 12th experiment, while lowest concentration hour